Exploration of the Gut-Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons.

Nutrients · 2022 · PMC9655149 · PMID 36364950

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borderline significanceno p-value reported

Additionally, in secondary exploratory mediation analyses, we found a potentially mediating role of cardiometabolic conditions, specifically hypercholesterolemia and fasting glycemia (diabetes with borderline significance).

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borderline non-significantno p-value reported

The indirect effect (NIE) operating through hypercholesterolemia was statistically significant (1.33 95% CI (1.05, 1.94)) and the one operating through diabetes was borderline non-significant (1.17 (0.99, 1.52)).

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