Depleted Calcium Stores and Increased Calcium Entry in Rod Photoreceptors of the <i>Cacna2d4</i> Mouse Model of Cone-Rod Dystrophy RCD4.

The difference between average ΔF/F MAX of WT (0.084 ± 0.017) and MUT (0.019 ± 0.004) rods was highly significant (*** t = 4.40122 with 32 df: p = 1.12099 × 10 −4 ).

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Indeed, upon normalization to membrane capacitance (Cm), which is proportional to the membrane surface area, the difference between average conductance values of WT (14.50 ± 2.80 pS/pF) and MUT rods (6.62 ± 3.29 pS/pF) did not reach statistical significance (t = 1.82014 with 8 df: p = 0.10623), suggesting the loss of synaptic channels contributes to the reduction in calcium current amplitudes in MUT rods.

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