Hypoxia-Inducible Factor-1 Alpha Expression Is Predictive of Pathological Complete Response in Patients with Breast Cancer Receiving Neoadjuvant Chemotherapy.

Cancers (Basel) · 2022 · PMC9656699 · PMID 36358811

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0800

boldest claim

The sentences

almost significantp = 0.06so close (0.05 < p ≤ 0.1)

In our study, pCR was an independent prognostic factor of longer DFS and almost significant for OS ( p = 0.06).

also in 1,858 other papers

did not reach statistical significancep = 0.08so close (0.05 < p ≤ 0.1)

As for OS, markers associated with decreased survival were HIF-1α positive (a trend that did not reach statistical significance, p = 0.08), Ki-67 positive ( p = 0.022), basal phenotype ( p = 0.007), pAKT negative ( p = 0.007) and ER negative ( p = 0.001).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.