Association between B-cell depletion and attack risk in neuromyelitis optica spectrum disorder: An exploratory analysis from N-MOmentum, a double-blind, randomised, placebo-controlled, multicentre phase 2/3 trial.

EBioMedicine · 2022 · PMC9664402 · PMID 36370634

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

did not reach statistical significancep = 0.07so close (0.05 < p ≤ 0.1)

Notably, in AQP4-IgG-seropositive participants, a trend towards lower AAR was noted in those with ≤4 cells/μL, but it did not reach statistical significance ( p = 0.07).

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