Mitochondrion-targeted RNA therapies as a potential treatment strategy for mitochondrial diseases.

Patients with mitochondrial disease had a higher frequency of mtDNA pathogenic mutations (62%) than nDNA (38%), and showed a trend where mtDNA mutations were prevalent in patients older than 2, and nDNA mutations were more frequently found in the infancy-onset disease group. 24 mtDNA mutations were highly associated with endocrinopathies and diabetes mellitus compared with nDNA mutations, suggesting a possible association of mtDNA mutations with age-related, non-mitochondrial diseases.

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