Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration.

J Exp Med · 2023 · PMC9664499 · PMID 36367776

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Moreover, Stat3 Δ/Δ mice treated with αCTLA-4 showed a trend toward elevated monocytes, Foxp3 + T cells (Treg), type 1 conventional DCs (cDC1s), and cDC2s in the colonic LP ( Fig. 2 J and Fig.

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