The c-Src activity (c-Src Tyr416 phosphorylation) appeared to be enhanced in R403Q-αMyHC mice compared to Ntg; however, it did not reach statistical significance (Fig. 1e, f , one-way ANOVA was used to compare groups).
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Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy.
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