Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD.

Although there were nominal ASD-associated increases in astrocyte (AST1) and decreases in lower-layer excitatory neuronal (EX7 and EX8) proportions, the changes were of small magnitude and reflect a nominally significant trend (FDR-corrected P- values > 0.18; Extended Data Fig. 9 and Supplementary Data 8 ).

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