Multi-omic analyses of changes in the tumor microenvironment of pancreatic adenocarcinoma following neoadjuvant treatment with anti-PD-1 therapy.

Cancer Cell · 2022 · PMC9669212 · PMID 36306792

Europe PMC DOI

hedged sentence

0.0810

closest p · 1.6× alpha

0.0810

boldest claim

The sentences

a near-significant trendp = 0.081so close (0.05 < p ≤ 0.1)

We found that higher density of TANs in post-treatment LAs was significantly (p = 0.011) associated with higher densities of tumor-infiltrating CD4 + PD-1 + T cells and, in a near-significant trend (p = 0.081), with higher densities of CD8 + PD-1 + T cells ( Figures 3I – 3K ) in the whole tumor areas.

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