Brivaracetam exhibits mild pro-inflammatory features in an <i>in vitro</i> astrocyte-microglia co-culture model of inflammation.

Front Cell Neurosci · 2022 · PMC9670320 · PMID 36406753

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Effects of BRV on cell-cell communication in astrocyte-microglia co-cultures Incubation of physiological M5 co-cultures with 0.5 μg/ml BRV for 24 h resulted in a slightly significant increase of gap-junctional cell-cell communication (increase of Lucifer Yellow stained cells to 41.45% ± 1.17 ( n = 20; p < 0.05: *; Figures 7A,C-1,C-2 ).

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