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Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing.

Front Immunol · 2022 · PMC9670805 · PMID 36405756

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a strong trendno p-value reported
For the second SNP–gene pair with TSFM , we found that the MS risk allele G of splice SNP rs10783847 showed a strong trend toward TSFM exon 6 and 7 inclusion of the transcript isoform ENST00000550559.

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