Anakinra or high-dose corticosteroids in COVID-19 pneumonia patients who deteriorate on low-dose dexamethasone: an observational study of comparative effectiveness.

However, a pre-planned Bayesian analyses of a traditional RCT suggested that dexamethasone 12 mg may be beneficial in patients with more severe respiratory impairment compared with DEXA6, although the difference in mortality did not reach statistical significance in the primary analyses ( COVID Steroid Trial Group et al., 2021 ).

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