Divergence and Convergence of Sex-Specific Time Trends in Ischemic Stroke: 10-Year Analysis of a State-Wide Registry in Germany.

15 In terms of time trends, a patient registry in the greater Cincinnati/Northern Kentucky area demonstrated a marked decrease of ischemic stroke incidence between 1993 and 2010 in male patients (238–165 per 100.000; P <0.01), whereas female patients only showed a nonsignificant trend (193–173 per 100.000; P =0.09). 16 An update of the same region with data until 2015 then showed declining incidences for both sexes except for male patients aged 20 to 44 years. 17 Similarly, data from the United States National Inpatient Sample have shown an increase of hospitalization fo

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8 However, a significant trend was revealed toward lower stroke incidence in female patients and a higher incidence in male patients over time, with a more pronounced risk for male patients aged 45 to 59 years.

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