Dopamine-inhibited POMCDrd2+ neurons in the ARC acutely regulate feeding and body temperature.

Interestingly, while male animals only showed a trend toward an anorexigenic effect and lower respiratory exchange ratio (RER) upon CNO administration compared with control littermates ( Figure 6, E–G ), female mice significantly and acutely responded with a decrease in food intake (16.2% ± 0.1% reduction over dark phase and additional 30.7% ± 0.1% reduction during light phase) and concomitant RER shift toward increased lipid utilization following CNO application ( Figure 6, J–L ).

also in 53,322 other papers