Thy-1 plays a pathogenic role and is a potential biomarker for skin fibrosis in scleroderma.

JCI Insight · 2022 · PMC9675443 · PMID 36066980

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showed a trendno p-value reported

TGF-β–treated SSc fibroblasts demonstrated a significant reduction in TGF-β–induced α-SMA expression ( P = 0.03) and showed a trend toward reduced Col1a1 expression, whereas no reduction in fibrotic gene expression was observed in healthy control fibroblasts ( Supplemental Figure 4 ).

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