Single-agent FOXO1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice.

Although the results did not reach statistical significance due to individual variability, they are consistent with a systemic effect of the locally produced insulin (see discussion). 4 Discussion We report the identification and characterization of potent, selective, and orally bioavailable FOXO1 inhibitors capable of inducing conversion of gut cells to insulin-producing, glucose-responsive β-like cells capable of normalizing glucose homeostasis in insulin-deficient diabetic mice.

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