Thirty novel sequence variants impacting human intracranial volume.

The exposures of Parkinson’s disease, neuroticism and migraine had a nominally significant effect on ICV in our MR analysis, but ADHD was not significant as an exposure for ICV ( P threshold < 0.05/29 = 1.7 × 10 −3 , β ADHD = 0.019, P ADHD =0.456; β Parkinson’s = 0.040, P Parkinson’s = 0.001; β neuroticism = 0.126, P neuroticism = 0.011; β migraine = −0.042, P migraine = 0.016; Supplementary Fig. 47 and Supplementary Table 8D ).

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