Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice.

In this analysis, we identified a highly significant overlap P-value with a positive correlation between the DG of adult Cn mutants (mutants vs. controls) and the DG of infant mice (2-week-old vs. 1-month-old) ( P = 2.7 × 10 –13 ; Fig. 3 d and e, Additional file 2 : Table S5), indicating a significant similarity in the gene expression patterns between them.

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The effect of the drug on the behavior was nominally significant but failed to reach study-wide significance; hence, this finding needs to be replicated in different cohorts.

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