One microRNA has the potential to target whole viral mRNAs in a given human coronavirus.

Front Microbiol · 2022 · PMC9686371 · PMID 36439806

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quite significantno p-value reported

Significantly, the common 5′ leader and 3’ UTR sequences in the nested set of mRNAs may be quite significant in that the commonalities suggest that for a given HCoV, a miRNA with the ability to bind to the 5′ leader or 3’ UTR may be able to target each mRNA, dramatically increasing the antiviral effect on the HCoV ( Figures 1c , f ).

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