Metformin Prevents Endothelial Dysfunction in Endometriosis through Downregulation of ET-1 and Upregulation of eNOS.

Biomedicines · 2022 · PMC9687337 · PMID 36359302

Europe PMC DOI

hedged sentences

0.1300

closest p · 2.6× alpha

0.1400

boldest claim

The sentences

showed a trendp = 0.13not close (p > 0.1)

Groups E and ME showed a trend towards increased cardiomyocyte area when compared with group S ( p = 0.13 and p = 0.19, respectively).

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a decreasing trendp = 0.14not close (p > 0.1)

VEGF expression presented a decreasing trend in group ME compared to E ( p = 0.14).

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a slight trendno p-value reported

On the contrary, expression of MIR155 that promotes cardiac hypertrophy by targeting calcium signaling [ 59 ] and inhibits angiogenesis [ 27 ] showed a slight trend to increase in metformin-treated relative to non-treated groups, which aligns with the higher cardiomyocyte areas found in group M.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.