Linking the Amyloid, Tau, and Mitochondrial Hypotheses of Alzheimer's Disease and Identifying Promising Drug Targets.

Biomolecules · 2022 · PMC9687482 · PMID 36421690

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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highly significantp < 10 −6actually significant

An umbrella review of systematic reviews and meta-analyses evaluating the association between environmental risk factors and AD showed that late-life depression and type 2 diabetes mellitus are the most significant; cancer, depression at any age, and physical activity are also highly significant ( p < 10 −6 ) in AD development.

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weakly significantno p-value reported

Weakly significant were also agreeableness, conscientiousness, and openness [ 67 ]. 2.1.2.

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