Surprisingly, considering the frequently reported loss of dopaminergic neurons in the SN of DLB patients, TH levels were not significantly reduced ( p = 0.17) but showed a clear trend towards a reduction in SN Surr. tissue of DLB patients (fold change CTRL/DLB: 2.9). 3.4. α-Synuclein Is Highly Abundant in NMGs of DLB Cases Since especially neuromelanin containing dopaminergic neurons are lost in the SN of DLB cases, it is assumed that neuromelanin or NMGs may be involved in the pathogenesis of DLB.
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There was also a slight trend of a higher abundance in CTRL NMGs compared to DLB NMGs (fold change: 1.5), which was consistent with the quantitative comparison, but it did not pass the threshold for significance (adjusted p -value: 0.24). α-synuclein was found to be significantly more abundant in NMGs of DLB cases, while its abundance in all other sample groups was comparable ( Figure 6 B).