Upregulation of YKL-40 Promotes Metastatic Phenotype and Correlates with Poor Prognosis and Therapy Response in Patients with Colorectal Cancer.

For stage II and stage IV CRC, p -values were not remarkably far from the standard 0.05 threshold, indicating a clear trend of significance.

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Interestingly, although an increasing trend in the serum YKL-40 concentration associated with the more advanced stages was not found, stage IV CRC patients showed the highest circulating level of the protein ( Figure 4 G).

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