Stress response protein REDD1 promotes diabetes-induced retinal inflammation by sustaining canonical NF-κB signaling.

J Biol Chem · 2022 · PMC9694114 · PMID 36309088

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showed a trendp = 0.08so close (0.05 < p ≤ 0.1)

Indeed, administration of an intravitreally administered siRNA targeting the REDD1 mRNA (PF-04523655) in patients with diabetic macular edema showed a trend toward improvement in BCVA when compared to focal/grid laser (+5.8 letters with 3 mg PF-04523655 versus +2.4 letters with laser, p = 0.08) ( 18 ).

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