a significant trendp = 0.044
The haplotype analysis, considering a minimum frequency in either group of at least 2%, showed a presence in the overall population of 7 haplotypes with comparable prevalence between cases and controls, with the exception of haplotype CAAC (rs2071590, rs2844482, rs2234694 and rs4880), which exhibited a significant trend toward a protective effect in migraine (OR = 0.49 (95% C.I.: 0.25–0.98), p = 0.044) ( Table 3 ).