Influence of recent direct-to-EVT trials on practical decision-making for the treatment of acute ischemic stroke patients.

12 , 13 Recently, five randomized trials sought to investigate whether EVT alone resulted in comparable outcomes to IVT followed by EVT: both DIRECT-MT 14 and DEVT 15 were able to demonstrate non-inferiority of the direct to EVT paradigm, while the MR CLEAN-NO IV (presented at ISC 2021), SWIFT-DIRECT (presented at ESOC 2021), and SKIP 16 results did not reach statistical significance for non-inferiority, despite comparable patient outcomes.

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