Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia.

In line with our findings, the results showed a highly significant increase in striatal GDNF mRNA levels in post-mortem striatum in individuals with schizophrenia compared to controls (Supplementary Fig.

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We also observed an increase in FEP patients with prior history of antipsychotic drugs compared with HCs, but this did not reach statistical significance due to high variance among the patients (Fig. 7A ).

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