Brain gyrification in bipolar disorder: a systematic review of neuroimaging studies.

Among the two studies that explored GI in relatives of BD, the first did not report differences between affected and unaffected offspring of BD and HC without a family history of BD in the IFG (Drobinin et al., 2019 ), a region previously proposed as a candidate endophenotype for BD (Cattarinussi et al., 2019 ), while the second showed a nearly significant reduction in GI in first-degree relatives of BD with cluster A personality disorder compared to HC (Nanda et al., 2014 ).

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