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Case report: Real-world experience using a personalized cancer-specific circulating tumor DNA assay in different metastatic melanoma scenarios.

Front Oncol · 2022 · PMC9713015 · PMID 36465349

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indeterminate significanceno p-value reported
False positivity represents another challenge that hinders the accurate interpretation of ctDNA, which could arise due to the detection of clonal hematopoiesis of indeterminate significance (CHIP) that is not tumor-specific ( 18 ).

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