A family-based study of genetic and epigenetic effects across multiple neurocognitive, motor, social-cognitive and social-behavioral functions.

This marker is a highly significant eQTL for MYOM2 on eQTLGen (P = 3.2717 × 10 –310 ) and GTEx (P = 9.5 × 10 –20 ) in whole blood.

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This marker remained at least nominally significant when adding a covariate for high risk status (i.e. for whether the child comes from a high risk family or a control family) to the model (P = 0.0312).

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Lastly, it should be noted that a POE may be significant with both paternal and maternal transmissions separately and there may still be a significant difference between them, if the association trends are discordant across both parental transmissions (i.e., the same allele may increase the score significantly when inherited from the mother but decrease it significantly when inherited from the father, or vice versa).

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