Evaluation of the acute oral toxicity and antipsychotic activity of a dual inhibitor of PDE1B and PDE10A in rat model of schizophrenia.

Although compound 2 (200 mg/kg) elicited a stronger social preference than compound 2 (100 mg/kg) and risperidone (0.5 mg/kg), the two groups have shown a strong trend toward the significant effect.

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