Dichloroacetate and thiamine improve survival and mitochondrial stress in a C. elegans model of dihydrolipoamide dehydrogenase deficiency.

For both DCA and thiamine a trend was seen toward increased protection from UPR mt induction, which became highly significant at 25 mM of either compound ( Supplemental Figure 6 , A and B).

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Indeed, the worm tissue homogenate showed a trend toward increased pyruvate levels and decreased lactate levels, which may relate to the analysis being performed on the homogenate of a population of entire organisms rather than the extracellular environment that is analyzed in standard human clinical blood-based analyses.

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