The Role of the Kynurenine Pathway in the (Patho) physiology of Maternal Pregnancy and Fetal Outcomes: A Systematic Review.

One study reported a reduced tryptophan concentration in FGR fetuses (QS = 5, mean (SD) μmol/L: 18.1 (14.8) vs 35.6 (7.3), N = 84, P < .001 (own analysis of supplemental data )), 53 and another study showed a trend toward a reduced tryptophan concentration in selective FGR twins compared to their appropriate-for-gestational-age co-twins (QS = 4, N = 20, no P -value reported). 55 In contrast, a metabolomics study revealed higher tryptophan concentrations in FGR (QS = 5, N = 43, P < .0001) and found that trypt

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