Whereas lung tissue levels of IL-1β were significantly increased in the mice subjected to the CFA/HDM model and unaffected by KE or dexamethasone ( Fig E1 , D ), CFA/HDM-induced increases in lung tissue IL-6 were reduced by dexamethasone but did not reach statistical significance in the group receiving dexamethasone plus KE ( Fig E1 , E ).
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Ketone body augmentation decreases methacholine hyperresponsiveness in mouse models of allergic asthma.
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