Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.

Conditional analysis of the top OPRM1 variants (rs1799971 and rs79704991; r 2 = 0.02) demonstrated that these variants are not independent as indicated by each variant falling below GWS when conditioned on the other; however, the variant effects remained nominally significant and there were no significant differences in the conditioned vs. unconditioned effect sizes.

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