LC3 protein levels in the spinal cord of i-min- Sod2 KO mice were similar to control mice, whereas p62 expression was increased in imn- Sod2 KO mice, however, this approach did not reach statistical significance (p = 0.057). 2.10.
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Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis.
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0.0570
0.0700
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close to significancep = 0.07
However, the B cells percentage in the spinal cord was elevated (the difference was close to significance, p = 0.07) in the i-mn- Sod2 KO mice compared to the controls ( Fig. 6 B).