A brain-wide form of presynaptic active zone plasticity orchestrates resilience to brain aging in Drosophila.

Indeed, BRP, Unc13A, Syn, and Dlg1 first increased almost linearly to arrive at a plateau at 30d to 40d (“early aging”) ( Fig 1B–1F ), while the ratios between activated, lipidated Atg8a (Atg8a-II) and inactive, unlipidated Atg8a (Atg8a-I) showed a clear trend of gradual reduction during early aging ( Fig 1B and 1H ), consistent with previous reports [ 10 , 35 , 46 ].

also in 19,460 other papers