Hypermethylation of <i>nc886</i> in HPV-positive oropharyngeal cancer and its clinical implications: An epigenome-wide association study.

Mol Ther Nucleic Acids · 2022 · PMC9722395 · PMID 36514351

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hedged sentences

0.3190

closest p · 6.4× alpha

0.3190

boldest claim

The sentences

did not reach statistical significancep = 0.319not close (p > 0.1)

0.455), although the difference did not reach statistical significance (p = 0.319), because more than 90% of cervical tumors are HPV16(+) and there were only nine HPV19(−) cervical tumors in the dataset.

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highly significantno p-value reported

In individual CpG site analysis, 1,107 CpG sites reached a false discovery rate (FDR) q value of <0.05, among which 25 sites had test statistic scores ( d ) of >5 and were defined as highly significant DMCs ( Table S1 ).

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