Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T-cell lymphoma.

EMBO Mol Med · 2022 · PMC9727928 · PMID 36341492

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0.0700

closest p · 1.4× alpha

0.2000

boldest claim

The sentences

a positive trendP = 0.07so close (0.05 < p ≤ 0.1)

We observed a significantly positive correlation for STAT3 and STAT5A ( STAT3 : Spearman r = 0.43, P = 0.04; STAT5A : Spearman r = 0.43, P = 0.04) and a positive trend for STAT5B ( STAT5B : Spearman r = 0.38, P = 0.07; Fig 2A–C ).

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showed a trendP = 0.20not close (p > 0.1)

In contrast, TP53 showed a trend for a negative correlation, whereas MYC , STAT1 , and SOCS1 did not correlate with disease clonality ( TP53 : Spearman r = −0.28, P = 0.20; MYC : Spearman r = 0.13, P = 0.54, STAT1 : Spearman r = 0.13, P = 0.56; SOCS1 : Spearman r = −0.12, P = 0.59), indicating that STAT3/5 copy number gains correlate with disease severity (Fig EV1B–E ).

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