When comparing lung ILC2 isolated from F-sham and OVX-E2 a significant reduction in il13 transcripts were detected by qRT-PCR ( p < 0.05); the reduction in il5 transcripts did not reach statistical significance ( p = 0.133) ( Figures 1D,E ).
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IL-33 induces NF-κB activation in ILC2 that can be suppressed by <i>in vivo</i> and <i>ex vivo</i> 17β-estradiol.
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