Inherited rare variants in homologous recombination and neurodevelopmental genes are associated with increased risk of neuroblastoma.

Although no CPG showed significant enrichment after FDR adjustment, BRCA1 showed the highest frequency of P/LP carriers in NB patients (N = 7, 1.05%) and yield a nominally significant enrichment (Firth's logistic regression P = 2.7 × 10 −3 , OR = 18.76) as well as BRCA2 (N = 4, 0.060%, Firth's logistic regression P = 0.032, OR = 11.21) ( Fig. 2 b, Table 2 , Table S11 ).

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