Plasma metabolic disturbances during pregnancy and postpartum in women with depression.

The “Citrate cycle” (TCA cycle) did not reach statistical significance in the control group, but it changed significantly in the PPD group as well as five other metabolic pathways, “Aminoacyl-tRNA biosynthesis,” “Arginine biosynthesis,” “Valine, leucine, and isoleucine biosynthesis,” “Alanine, aspartate, and glutamate metabolism,” and “Pantothenate and CoA biosynthesis.” Compared with metabolites that changed significantly from pregnancy to postpartum in the control group, 37 metabolites showed different alterations in the PPD group ( Figure 4 C, See also Table S9 ).

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