Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration.

Transl Psychiatry · 2022 · PMC9734180 · PMID 36494352

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did not reach statistical significanceno p-value reported

We observed a modest increase in proteins involved in lysosomal biogenesis (total TFEB, phospho-TFEB, and Rab7 [ 51 ]) in MAPT p.R406W neurons, however, the difference compared to isogenic, control neurons did not reach statistical significance (Supplemental Fig. 2 ).

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