Paeoniflorin, a constituent of Kami-shoyo-san, suppresses blood glucose levels in postmenopausal diabetic mice by promoting the secretion of estradiol from adipocytes.

KS significantly decreased glucose concentration at a high concentration (1 mg/mL), whereas KS-PR and PR showed a decreasing trend ( Fig. 5 A).

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PF-treated mice showed a trend toward increased blood estradiol levels in a dose-dependent manner ( Fig. 8 A), whereas the mice showed significantly decreased blood adiponectin levels in a concentration-dependent manner ( Fig. 8 B).

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