Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females.

Cells · 2022 · PMC9737364 · PMID 36497141

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Levels of Adam10 and Adam17 mRNAs in 5xFAD were previously reported as increased at one month of age, and by nine months of age, Adam10 mRNA was decreased and Adam17 also showed a trend of reduction at the same age [ 41 ].

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