Oxidative Stress Correlates with More Aggressive Features in Thyroid Cancer.

When we performed a paired analysis with the corresponding normal tissues, a highly significant difference in H 2 O 2 production was found in BRAF + TERT ( p = 0.009), BRAF only ( p = 0.003), ALL BRAF ( p < 0.0001), RET or RAS mutated ( p = 0.02), and ALL MUT tumors ( p < 0.0001) but not in non-mutated PTCs ( p = 0.12) ( Figure 2 , panel B). 3.3.

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Moreover, H 2 O 2 generation in DTCs showed a trend toward a correlation with extrathyroidal extension ( p = 0.06) ( Figure 3 ). 3.4.

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