The Use of Zidovudine Pharmacophore in Multi-Target-Directed Ligands for AIDS Therapy.

Molecules · 2022 · PMC9738661 · PMID 36500608

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highly significantno p-value reported

In the AIDS drug discovery field, the design of new MTDLs based on the AZT scaffold seems highly significant.

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a clear trendno p-value reported

Of note, the antiviral activity within this series demonstrated a clear trend in decreasing potency with the increasing number of methylene units of the linker (n > 6).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.