Mesoscopic Mapping of Visual Pathway in a Female 5XFAD Mouse Model of Alzheimer's Disease.

Taken together, the results of our study using 5XFAD mice demonstrated that (1) retinal projections to the SCN, dLGN, IGL, and vLGN were significantly impaired in the early stages of AD, (2) connections of the retina with dLGN and SC were disrupted in the late stages of AD, (3) the visual pathways in the brain with AD showed a trend towards accelerated degeneration during the AD progression, and (4) the visual circuits in the healthy brain degenerated according to aging.

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