RIPOR2 Expression Decreased by HPV-16 E6 and E7 Oncoproteins: An Opportunity in the Search for Prognostic Biomarkers in Cervical Cancer.

Cells · 2022 · PMC9740487 · PMID 36497200

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In this work, the RNAseq analysis revealed that PFKFB4 is overexpressed in the presence of E6 and E7, and the data obtained by qPCR showed a trend towards increased expression of this gene, although not significant; probably because PFBKB4 expression could be highly sensitive to regulation by other cancer-associated processes such as hypoxia [ 50 ], which warrants further study.

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