A recent analysis of haplotypes comprising the rs6857, rs2075650, rs769449, rs429358, and rs7412 SNPs mapped to the APOE gene cluster also suggested a nominally significant adverse effect on longevity in carriers of the ɛ3/ɛ3 genotype, that is, independently of the ɛ4 and ɛ2 alleles (Sebastiani et al., 2019 ).
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APOE ɛ4 allele and TOMM40-APOC1 variants jointly contribute to survival to older ages.
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